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(±) -Evodiamine

CAT: 0804-HY-N0114A-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N0114A-01Size:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(±) -Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±) -Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis[1].
CAS Number
518-18-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/racemic-evodiamine.html
Purity
99.97
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=CC=CC=C2N(C)C(N1CC3)C4=C3C5=CC=CC=C5N4
Molecular Formula
C19H17N3O
Molecular Weight
303.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Dong G, et, al. New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. J Med Chem. 2012 Sep 13;55 (17) :7593-613.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I

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