A-485

• Description:

  A-485, a chemical probe, is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Epigenetic Reader Domain; Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/A-485.html

• Purity:

  99.87

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N1CC (N ([C@@H] (C) C (F) (F) F) CC2=CC=C (F) C=C2) =O) [C@]3 (OC1=O) C4=CC=C (NC (NC) =O) C=C4CC3

• Molecular Formula:

  C25H24F4N4O5

• Molecular Weight:

  536.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lasko LM, et al. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 Oct 5;550 (7674) :128-132.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CBP/p300

• CAS Number:

  1889279-16-6