A-485

• UNSPSC Description:

  A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8?nM and 2.6?nM for p300 and CBP histone acetyltransferase (HAT), respectively[1].

• Target Antigen:

  Epigenetic Reader Domain; Histone Acetyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/A-485.html

• Purity:

  99.87

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(N1CC(N([C@@H](C)C(F)(F)F)CC2=CC=C(F)C=C2)=O)[C@]3(OC1=O)C4=CC=C(NC(NC)=O)C=C4CC3

• Molecular Weight:

  536.48

• References & Citations:

  [1]Lasko LM, et al. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. 2017 Oct 5;550(7674):128-132.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1889279-16-6