Mal-PEG2-VCP-Eribulin

Mal-PEG2-VCP-Eribulin

• CAS Number: 2130869-18-8
• UNSPSC Description: Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates[1][2][3].
• Target Antigen: Drug-Linker Conjugates for ADC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mal-peg2-vcp-eribulin.html
• Purity: 99.82
• Solubility: DMSO : 10 mg/mL (ultrasonic;warming)
• Smiles: C=C1C[C@@]2([H])O[C@@]1([H])CC[C@]3([H])O[C@](C([C@H](C)C3)=C)([H])C[C@@]4([H])[C@]([C@@H](OC)[C@@H](C[C@H](O)CNC(OCC5=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN6C(C=CC6=O)=O)=O)=O)=O)C=C5)=O)O4)([H])CC(C[C@]7([H])O[C@]8([H])[C@]9([H])O[C@@]%10(O[C@@]%11([H])[C@@](O[C@]9([H])[C@@]%11([H])O[C@@]8([H])CC7)([H])C%10)CC2)=O
• Molecular Weight: 1374.57
• References & Citations: [1]Earl F Albone, et al. Eribulin-based antibody-drug conjugates and methods of use. US20170252458A1.|[2]Towle MJ, et al. Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 2011 Jan 15;71(2):496-505.|[3]Watanabe K, et al. Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo. Oncotarget. 2019 Jan 4;10(2):161-174.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: No Development Reported