Mal-PEG2-acid

• Description :

  Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule[1]. Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319, H335

• Target :

  ADC Linker; PROTAC Linkers

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mal-peg2-acid.html

• Purity :

  99.90

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)CCOCCOCCN1C(C=CC1=O)=O

• Molecular Formula :

  C11H15NO6

• Molecular Weight :

  257.24

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Zhao, Yongxin, et al. Cytotoxin molecule, conjugate and preparation method and application thereof. Faming Zhuanli Shenqing (2019), CN 109912683 A 20190621.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Non-cleavable Linker; PEG Linkers

• CAS Number :

  [1374666-32-6]