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5-Methyluridine

CAT: 0804-HY-W009444-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009444-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Methyluridine (m5U) is an RNA modified nucleotide generated by RNA methyltransferases (such as TrmA and RumA), which mainly targets specific uracil sites in RNA molecules such as the T arm of tRNA and rRNA. 5-Methyluridine relies on enzyme recognition of RNA secondary/tertiary structures (such as the T loop of tRNA or the specific stem-loop structure of rRNA) and participates in physiological processes such as translation accuracy and ribosome function by stabilizing RNA folding or regulating base pairing[1][2][3].
CAS Number
1463-10-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-Methyluridine.html
Concentration
10mM
Purity
99.88
Solubility
DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C10H14N2O6
Molecular Weight
258.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Hur S, et al. Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. J Biol Chem. 2006 Dec 22;281 (51) :38969-73.|[2]Jones JD, et al. Conserved 5-methyluridine tRNA modification modulates ribosome translocation. bioRxiv [Preprint]. 2023 Nov 12:2023.11.12.566704.|[3]Yang TH, et al. Intracellular levels of S-adenosylhomocysteine but not homocysteine are highly correlated to the expression of nm23-H1 and the level of 5-methyldeoxycytidine in human hepatoma cells with different invasion activities. Nutr Cancer. 2006;55 (2) :224-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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