Blovacitinib

CAT: 0804-HY-152080-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-152080-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Blovacitinib (TUL01101) is a potent, selective and orally active JAK1 inhibitor, with an IC50s of 3, 37, 1517 and 36 nM for JAK1, JAK2, JAK3, and TYK2, respectively. Blovacitinib can be used for the research of rheumatoid arthritis[1].

CAS Number

2411222-97-2

Product Name Alternative

TUL01101

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tul01101.html

Purity

99.71

Solubility

DMSO : ≥ 200 mg/mL

Smiles

O=C(NC1=NN2C(C=CC=C2C3CCC4(CC3)CN(C4)C([C@@H]5CC5(F)F)=O)=N1)C6CC6

Molecular Formula

C22H25F2N5O2

Molecular Weight

429.46

References & Citations

[1]Zhou S, et, al. Identification of TUL01101: A Novel Potent and Selective JAK1 Inhibitor for the Treatment of Rheumatoid Arthritis. J Med Chem. 2022 Dec 22;65 (24) :16716-16740.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK1; JAK2; JAK3; Tyk2

Blovacitinib

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