NHC-triphosphate (tetraammonium)

NHC-triphosphate (tetraammonium)

• UNSPSC Description: NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form[1]. NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].
• Target Antigen: Endogenous Metabolite; Enterovirus; HCV; SARS-CoV; Topoisomerase
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/nhc-triphosphate-tetraammonium.html
• Smiles: O[C@H]1[C@H](N(C=C/C2=N/O)C(N2)=O)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1O.N.N.N.N
• Molecular Weight: 567.28
• References & Citations: [1]Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.bioRxiv. 2021 Jul 21:2021.07.21.453274. |Nat Struct Mol Biol. 2021 Sep;28(9):740-746. |ACS Bio Med Chem Au. October 24, 2022.|Commun Biol. 2022 Feb 22;5(1):154.|J Biol Chem. 2021 May 11;100770.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|ACS Sens. 2022 May 27;7(5):1564-1571.
• Shipping Conditions: Dry Ice