MFZ 10-7

CAT: 0804-HY-103575-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103575-01Size:1 mg

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Description

MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CAS Number

1224431-15-5

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mfz-10-7.html

Purity

99.70

Solubility

DMSO : 17.86 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=CC(C#CC2=NC(C)=CC=C2)=CC(F)=C1

Molecular Formula

C15H9FN2

Molecular Weight

236.24

References & Citations

[1]Keck TM, et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR5

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MFZ 10-7

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