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BAY 41-2272

CAT: 0804-HY-12376-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12376-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research[1][2].
CAS Number
256376-24-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/BAY-41-2272.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 17.5 mg/mL (ultrasonic)
Smiles
NC1=NC(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)=NC=C1C5CC5
Molecular Formula
C20H17FN6
Molecular Weight
360.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Makrynitsa GI, et al. Mapping of the sGC Stimulator BAY 41-2272 Binding Site on H-NOX Domain and Its Regulation by the Redox State of the Heme. Front Cell Dev Biol. 2022 Jun 17;10:925457. |[2]Vogel J, et al. sGC stimulation lowers elevated blood pressure in a new canine model of resistant hypertension. Hypertens Res. 2021 Dec;44 (12) :1568-1577.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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