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Stearoylcarnitine

CAT: 0804-HY-113202-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113202-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2[1][2][3][4][5].
CAS Number
25597-09-5
Product Name Alternative
5-(4-Phenoxybutoxy)psoralen, ZM-211973
UNSPSC
12352211
Target
Endogenous Metabolite; GlyT; PKC
Type
Natural Products
Related Pathways
Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Stearoylcarnitine.html
Purity
99.91
Solubility
DMSO : 0.95 mg/mL (ultrasonic; warming; adjust pH to 6 with 0.1 N NaOH; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O
Molecular Formula
C25H49NO4
Molecular Weight
427.66
References & Citations
[1]Aichler M, et al. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metab. 2017 Jun 6;25 (6) :1334-1347.e4.|[2]Dave AM, et al. Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model. Metabolites. 2022 May 22;12 (5) :467.|[3]Bell FP. Carnitine esters: novel inhibitors of plasma lecithin: cholesterol acyltransferase in experimental animals but not in man (Homo sapiens) . Int J Biochem. 1983;15 (2) :133-6.|[4]Li XZ, et al. Cerebral metabonomics study on Parkinson's disease mice treated with extract of Acanthopanax senticosus harms. Phytomedicine. 2013 Oct 15;20 (13) :1219-29.|[5]da Luz G, et al. Triterpene derivative: A potential signaling pathway for the fern-9 (11) -ene-2α,3β-diol on insulin secretion in pancreatic islet. Life Sci. 2016 Jun 1;154:58-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

Alternative Products

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BA7426-100Stearoylcarnitine
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A18721-10Stearoylcarnitine 10mg
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A18721-100Stearoylcarnitine 100mg
A18721-25Stearoylcarnitine 25mg
A18721-10mM-DStearoylcarnitine 10mM * 1mL in DMSO
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