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E-55888

CAT: 0804-HY-113866Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-113866Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E-55888 is a selective and potent agonist of 5-HT7 receptor and 5-HT1A receptor with Ki values of 2.5 nM and 700 nM, respectively, which has analgesic and antinociceptive effects. E-55888 reduces the nociceptive response of Capsaicin sensitized mice[1][2].
CAS Number
1034142-33-0
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CC1=C(C2=CC(CCN(C)C)=CC=C2)C(C)=NN1C
Molecular Formula
C16H23N3
Molecular Weight
257.37
References & Citations
[1]Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141 (3) :239-247.|[2]Hansen HD, et al. Labeling and preliminary in vivo evaluation of the 5-HT (7) receptor selective agonist [ (11) C]E-55888. Bioorg Med Chem Lett. 2015 May 1;25 (9) :1901-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT7 Receptor

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