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Acoltremon

CAT: 0804-HY-108449-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108449-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].
CAS Number
68489-09-8
Product Name Alternative
WS-12; AR-15512; AVX-012
UNSPSC
12352005
Hazard Statement
H410
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/acoltremon.html
Purity
99.13
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C([C@H]1[C@H](C(C)C)CC[C@@H](C)C1)NC2=CC=C(OC)C=C2
Molecular Formula
C18H27NO2
Molecular Weight
289.41
Precautions
H410
References & Citations
[1]Beck B, et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41 (3) :285-94.|[2]Ma S, et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008 Oct;21 (4) :370-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
TRPM8

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