L-Naproxen

• Description :

  L-Naproxen ((R) -Naproxen) is an enantiomer of (S) -Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory agent (NSAID) [1][2][3].

• Product Name Alternative :

  (R) -Naproxen

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/l-naproxen.html

• Concentration :

  10mM

• Purity :

  99.88

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  COC1=CC=C2C(C=CC([C@H](C(O)=O)C)=C2)=C1

• Molecular Formula :

  C14H14O3

• Molecular Weight :

  230.26

• Precautions :

  H302

• References & Citations :

  [1]Sonika Batra, et al. Enantiomeric Resolution of (RS) -Naproxen and Application of (S) - Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24 (8) :758-780.|[2]M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23 (10) :1099-103.|[3]Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10 (11) :e0142182.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [23979-41-1]