Naproxen

• Description:

  Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.

• Product Name Alternative:

  (S) -Naproxen

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335, H361, H402, H411

• Target:

  Autophagy; COX

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Naproxen.html

• Purity:

  99.98

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : 75 mg/mL (ultrasonic; warming)

• Smiles:

  C[C@H](C(O)=O)C1=CC2=CC=C(OC)C=C2C=C1

• Molecular Formula:

  C14H14O3

• Molecular Weight:

  230.26

• Precautions:

  H302, H315, H319, H335, H361, H402, H411

• References & Citations:

  [1]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90 (24) :11693-7.|[2]Rosa AC, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351 (2) :308-16.|[3]Krekels EH, et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  COX-1; COX-2

• CAS Number:

  [22204-53-1]