K145 (hydrochloride)

• UNSPSC Description:

  K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1].

• Target Antigen:

  Apoptosis; SphK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Immunology/Inflammation

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/k145-hydrochloride.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(N(CCN)C/1=O)SC1=C/CCC2=CC=C(OCCCC)C=C2.[H]Cl

• Molecular Weight:

  384.92

• References & Citations:

  [1]Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013;8(2):e56471.Biochem Biophys Res Commun. 2021 Sep 28;580:1-6.|Am J Cancer Res. 2019 Mar 1;9(3):546-561.|Biochem Biophys Res Commun. 2017 Nov 4;493(1):286-290. |Channels. 2020 Dec;14(1):216-230.|Exp Mol Pathol. 2016 Feb;100(1):51-8. |Sci China Life Sci. 2021 May 27;1-21.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1449240-68-9