Human Interferon gamma Recombinant Rabbit Monoclonal Antibody [PS01-76] - BSA and Azide free (Detector)

Human Interferon gamma Recombinant Rabbit Monoclonal Antibody [PS01-76] - BSA and Azide free (Detector)

• Description: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL. Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation.
• Product Name Alternative: IF 1 antibody IFG antibody IFI antibody ifn g antibody IFN gamma antibody IFN immune antibody IFN, immune antibody IFN-gamma antibody IFNG antibody IFNG_HUMAN antibody Immune interferon antibody Interferon gamma antibody Type II Interferon antibody
• Abbreviation: Interferon gamma IFN-gamma Immune interferon IFNG
• CAS Number: 9000-83-3
• Swiss Prot: P01579 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human Interferon gamma aa 24-161.
• Isotype: IgG
• Clone: PS01-76
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Positive Control: Recombinant standard Human Interferon gamma protein (HA210762).
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PS01-75] to Human Interferon gamma (Capture) (HA721574) and recombinant standard Human Interferon gamma protein (HA210762). The reference range value is 13.7-10,000pg/ml.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes