Roburic acid

• Description:

  Roburic acid, a tetracyclic triterpenoid found in Gentiana macrophylla, acts as an inhibitor of COX, with IC50s of 5 and 9 μM for COX-1 and COX-2, respectively[1].

• UNSPSC:

  12352211

• Target:

  COX

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/roburic-acid.html

• Purity:

  99.93

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C[C@] (C1=CC2) (CC[C@]3 (C) [C@@]1 ([H]) [C@@H] (C) [C@H] (C) CC3) [C@@] (CC[C@H]4C (C) =C) (C) [C@@]2 ([H]) [C@@]4 (C) CCC (O) =O

• Molecular Formula:

  C30H48O2

• Molecular Weight:

  440.70

• References & Citations:

  [1]Cao H, et al. Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation. Pharmacol Res. 2010 Jun;61 (6) :519-24.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  COX-1; COX-2

• CAS Number:

  6812-81-3