RegisterLogin

Gomisin J

CAT: 0804-HY-N0385-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0385-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc[1][2][3].
CAS Number
[66280-25-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; CaMK; Keap1-Nrf2; NF-κB; NO Synthase
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gomisin-j.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C(OC)=C(C2=C(OC)C(OC)=C(O)C=C2CC(C)C(C)C3)C3=C1
Molecular Formula
C22H28O6
Molecular Weight
388.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Ye BH, et al. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res. 2015 Mar;38 (3) :169-77.|[2]Kim M, et al. Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. J Agric Food Chem. 2015 Nov 11;63 (44) :9729-39.|[3]Min X, et al. Gomisin J attenuates cerebral ischemia/reperfusion injury by inducing anti-apoptotic, anti-inflammatory, and antioxidant effects in rats. Bioengineered. 2022 Mar;13 (3) :6908-6918.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AMPK; Calcium Channel; eNOS

Related Products

CatalogName
HY-N7825-01Gomisin L1
HY-N2246-01Gomisin H
HY-N8159-01Gomisin U
HY-N0858-01Gomisin G
HY-N2235-01Gomisin O
HY-N7958Gomisin F
HY-N7485-01Gomisin K1
HY-N3963-01Gomisin M2
HY-N6866-01Gomisin N
HY-N7310-01Gomisin E

Alternative Products

CatalogName
MBS3608844-01Gomisin A
M29157-01Gomisin O
M31319-01Gomisin F
M38838-01Gomisin K1
MBS3617530-01Gomisin D
278265-01Gomisin C
300377Gomisin G
380398Gomisin S
AB2333Gomisin U
BUP23943-01Gomisin H

Popular Products