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TRULI

CAT: 0804-HY-138489-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138489-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].
CAS Number
1424635-83-5
Product Name Alternative
Lats-IN-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ser/Thr Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/truli.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
Molecular Formula
C18H14N4OS
Molecular Weight
334.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Truli

TRULI is a pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine substituted by a N-(3-benzyl-1,3-thiazol-2(3H)-ylidene)carboxamide group at position 3. It is a potent and ATP-competitive inhibitor of LATS1 and LATS2 kinases, and a YAP signaling activator. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of benzenes, a member of 1,3-thiazoles, a pyrrolopyridine and an enamide.

CAS Number1424635-83-5
PubChem CID71890885
IUPAC NameN-(3-benzyl-1,3-thiazol-2-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
Molecular FormulaC18H14N4OS
Molecular Weight334.4
XLogP3
Topological Polar Surface Area86.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity529
SMILES
C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4
InChI
InChI=1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20)
InChIKey
VTXBMVZVPUSAJF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Truli
CAS: 1424635-83-5
CID: 71890885
Formula: C18H14N4OS
MW: 334.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.4
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass334.08883226
Monoisotopic Mass334.08883226
Topological Polar Surface Area86.7 Ų
Heavy Atom Count24
Formal Charge0
Complexity529
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
E1061-10mM/1mLTRULI

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