Miro1 Reducer

• Description:

  Miro1 Reducer is a small molecule that can repair this defect of Miro1 in Parkinson's disease (PD) fibroblasts. Miro1 Reducer reduces the delayed mitophagy phenotype in PD fibroblasts. Miro1 Reducer reduces Miro1 protein levels in dose-dependent manner (IC50 = 7.8 mM) [1].

• UNSPSC:

  12352005

• Target:

  Mitophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/miro1-reducer.html

• Purity:

  99.73

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=CC(F)=CC=C1)NC2=CC=C(NC3=NC=NC(N4C=NC=C4)=C3)C=C2.Cl

• Molecular Formula:

  C20H17ClFN7O

• Molecular Weight:

  425.85

• References & Citations:

  [1]Hsieh CH, et al. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metab. 2019 Dec 3;30 (6) :1131-1140.e7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2624336-91-8]