Products for Research Use Only
RegisterLogin

Tirapazamine

CAT: 0804-HY-13767-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13767-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells[1][2].
CAS Number
27314-97-2
Product Name Alternative
SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tirapazamine.html
Purity
99.02
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
NC1=[N+]([O-])C2=CC=CC=C2[N+]([O-])=N1
Molecular Formula
C7H6N4O2
Molecular Weight
178.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Cai TY, et al. Tirapazamine sensitizes hepatocellular carcinoma cells to topoisomerase I inhibitors via cooperative modulation of hypoxia-inducible factor-1α. Mol Cancer Ther. 2014 Mar;13 (3) :630-42.|[2]Sliwinska J, et al. Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca2? balance protein levels. Oxid Med Cell Longev. 2012;2012:890826.|[3]Lee, Donghyun, et al. Optimized Combination of Photodynamic Therapy and Chemotherapy Using Gelatin Nanoparticles Containing Tirapazamine and Pheophorbide a. ACS applied materials & interfaces vol. 13,9 (2021) : 10812-10821. |[4]Romero, José, et al. Electronic structure and reactivity of tirapazamine as a radiosensitizer. Journal of molecular modeling vol. 27,6 177. 22 May. 2021.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
MBS385736-01Tirapazamine
A12754-10Tirapazamine 10mg
A12754-1000Tirapazamine 1000mg
A12754-250Tirapazamine 250mg
A12754-25Tirapazamine 25mg
A12754-500Tirapazamine 500mg
A12754-100Tirapazamine 100mg
A12754-50Tirapazamine 50mg
A12754-10mM-DTirapazamine 10mM * 1mL in DMSO
MBS6065891-013-Amino-1,2,4-benzotriazine-1,4-dioxide (SR-4233, Tirapazamine)

Popular Products