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L-Asparagine

CAT: 0804-HY-N0667-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-N0667-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5].
CAS Number
70-47-3
Product Name Alternative
(-) -Asparagine; Asn; Asparamide
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; DNA/RNA Synthesis; Endogenous Metabolite
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/L-Asparagine.html
Purity
98.0
Solubility
H2O : 6.67 mg/mL (ultrasonic)
Smiles
N[C@H](C(O)=O)CC(N)=O
Molecular Formula
C4H8N2O3
Molecular Weight
132.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Batool T, et al. A Comprehensive Review on L-Asparaginase and Its Applications. Appl Biochem Biotechnol. 2016 Mar;178 (5) :900-23.|[2]Asselin BL, et al. In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase. Cancer Res. 1989 Aug 1;49 (15) :4363-8.|[3]Horvath TD, et al. Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer. Metabolites. 2019 Jan 9;9 (1) :10.|[4]Kravtzoff R, et al. Erythrocytes as carriers for L-asparaginase. Methodological and mouse in-vivo studies. J Pharm Pharmacol. 1990 Jul;42 (7) :473-6.|[5]Ilaria M Michelozzi, et al. Acute myeloid leukaemia niche regulates response to L-asparaginase. Br J Haematol. 2019 Aug;186 (3) :420-430. doi: 10.1111/bjh.15920.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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