BRD9876

CAT: 0804-HY-110208-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110208-01Size:50 mg
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Description
BRD9876 is the "rigor" inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research[1][2][3][4].
CAS Number
[32703-82-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kinesin; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd9876.html
Purity
99.37
Solubility
DMF : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)(C1=CC2=CC(C#N)=C(C#N)C=C2C=C1)C
Molecular Formula
C16H14N2
Molecular Weight
234.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Shrikanta Chattopadhyay, et al. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10;10 (5) :755-770.|[2]Geng-Yuan Chen, et al. Eg5 Inhibitors Have Contrasting Effects on Microtubule Stability and Metaphase Spindle Integrity. ACS Chem Biol. 2017 Apr 21;12 (4) :1038-1046.|[3]Chieh-Ting Fang, et al. HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors. Cell Death Dis. 2020 Sep 1;11 (8) :715.|[4]Anke Maes, et al. The therapeutic potential of cell cycle targeting in multiple myeloma. Oncotarget. 2017 Jun 28;8 (52) :90501-90520.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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