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Esmolol (hydrochloride)

CAT: 0804-HY-B1392-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1392-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol hydrochloride attenuates post resuscitation myocardial dysfunction. Esmolol hydrochloride improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers[1][2][3].
CAS Number
81161-17-3
UNSPSC
12352005
Hazard Statement
H319
Target
Adrenergic Receptor; Aldose Reductase; Apoptosis; Caspase; Neurokinin Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Esmolol-hydrochloride.html
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 50 mg/mL
Smiles
O=C(OC)CCC1=CC=C(OCC(O)CNC(C)C)C=C1.[H]Cl
Molecular Formula
C16H26ClNO4
Molecular Weight
331.83
Precautions
H319
References & Citations
[1]Kulkarni SA, et al. Novel topical esmolol hydrochloride improves wound healing in diabetes by inhibiting aldose reductase, generation of advanced glycation end products, and facilitating the migration of fibroblasts. Front Endocrinol (Lausanne) . 2022 Aug 23;13:926129. |[2]Wang LL, et al. Esmolol activates endogenous neurokinin activity inhibiting infarction-induced arrhythmias in rats: novel mechanisms of anti-arrhythmia. Regul Pept. 2013 Sep 10;186:116-22.|[3]Zhang Q, et al. Combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction in a porcine model of cardiac arrest. PLoS One. 2013 Dec 18;8 (12) :e82677.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Caspase 3; β adrenergic receptor

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