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Aceclidine (hydrochloride)

CAT: 0804-HY-32067A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-32067A-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aceclidine (Quinuclidin-3-yl acetate) hydrochloride is a modulator of M3 muscarinic acetylcholine receptor and a M1 receptor agonist (EC50: 40 μM) . Aceclidine hydrochloride is a cycloplegic agent, a surfactant, a tonicity adjustor and optionally a viscosity enhancer and an antioxidant. Aceclidine hydrochloride has the potential for the research of disorders such as refractive errors of the eye, xerostomia, Sjogren's syndrome, glaucoma, conjunctivitis, lacrimal gland disease, and esotropia[1][2][3].
CAS Number
6109-70-2
Product Name Alternative
Quinuclidin-3-yl acetate (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301+H311
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aceclidine-hydrochloride.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(OC1C[N@@]2CC[C@H]1CC2)=O.Cl
Molecular Formula
C9H16ClNO2
Molecular Weight
205.68
Precautions
H301+H311
References & Citations
[1]Gerald Horn, et al. Storage Stable Compositions and Methods for the Treatment of Refractive Errors of the Eye. Patent US20150290125A1.|[2]Thomas G. Gant, et al. Imidazole modulators of muscarinic acetylcholine receptor m3. Patent US20110091459A1.|[3]Cui Y, et al. Enhancement of memory function in aged mice by a novel derivative of xanomeline. Cell Res. 2008 Nov;18 (11) :1151-3. |[4]Hagan JJ, et al. Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics. Psychopharmacology (Berl) . 1989;98 (3) :347-56.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MAChR1; mAChR3

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