Clavulanate (lithium)

• Description:

  Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H360

• Target:

  Antibiotic; Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/clavulanate-lithium.html

• Concentration:

  10mM

• Purity:

  99.87

• Solubility:

  DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C([C@@H](/C(O[C@]1([H])C2)=C/CO)N1C2=O)O[Li]

• Molecular Formula:

  C8H8LiNO5

• Molecular Weight:

  205.09

• Precautions:

  H360

• References & Citations:

  [1]Reading C, et al. Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May; 11 (5) : 852–857.|[2]Stokes DH, et al. Bactericidal effects of amoxycillin/clavulanic acid against intracellular Legionella pneumophila in tissue culture studies. J Antimicrob Chemother. 1989 Apr;23 (4) :547-56.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  β-lactam

• Citation 01:

  BioRxiv. 2024 May 10.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Biomed Res Int. 2018 Jul 2:2018:3579832.|Eur J Pharmacol. 2024 Dec 5:984:177017.|Genomics. 2022 Nov;114 (6) :110527.|Int J Mol Sci. 2023 Oct 27;24 (21) :15657.|J Antimicrob Chemother. 2025 Nov 5:dkaf408.

• CAS Number:

  61177-44-4