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CGP52411

CAT: 0804-HY-103442-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103442-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 μM. CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates associated with Alzheimer's disease[1][2].
CAS Number
145915-58-8
Product Name Alternative
DAPH
UNSPSC
12352005
Hazard Statement
H302
Target
Amyloid-β; EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cgp52411.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(C2=C1C=C(NC3=CC=CC=C3)C(NC4=CC=CC=C4)=C2)=O
Molecular Formula
C20H15N3O2
Molecular Weight
329.35
Precautions
H302
References & Citations
[1]Buchdunger E, et al. 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc Natl Acad Sci U S A. 1994 Mar 15;91 (6) :2334-8.|[2]Blanchard BJ, et al. Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc Natl Acad Sci U S A. 2004 Oct 5;101 (40) :14326-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

Chemical Information

4,5-Dianilinophthalimide

4,5-dianilinophthalimide is phthalimide substituted at the 4- and 5-positions by anilino groups. It has a role as a geroprotector and a tyrosine kinase inhibitor.

CAS Number145915-58-8
PubChem CID1697
IUPAC Name5,6-dianilinoisoindole-1,3-dione
Molecular FormulaC20H15N3O2
Molecular Weight329.4
XLogP3.8
Topological Polar Surface Area70.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity453
SMILES
C1=CC=C(C=C1)NC2=C(C=C3C(=C2)C(=O)NC3=O)NC4=CC=CC=C4
InChI
InChI=1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)
InChIKey
AAALVYBICLMAMA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4,5-Dianilinophthalimide
CAS: 145915-58-8
CID: 1697
Formula: C20H15N3O2
MW: 329.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight329.4
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass329.116426730
Monoisotopic Mass329.116426730
Topological Polar Surface Area70.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity453
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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