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CGP52411

CAT: 0931-T10782-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T10782-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
145915-58-8
Target
Beta Amyloid, EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Neuroscience, Angiogenesis
Purity
0.9978
Bioactivity
CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM) . CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid Aβ42 fibril aggregates. CGP52411 can be used in studies about Alzheimer's diseases.
Smiles
O=C1NC(=O)c2cc(Nc3ccccc3)c(Nc3ccccc3)cc12
Molecular Formula
C20H15N3O2
Molecular Weight
329.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

4,5-Dianilinophthalimide

4,5-dianilinophthalimide is phthalimide substituted at the 4- and 5-positions by anilino groups. It has a role as a geroprotector and a tyrosine kinase inhibitor.

CAS Number145915-58-8
PubChem CID1697
IUPAC Name5,6-dianilinoisoindole-1,3-dione
Molecular FormulaC20H15N3O2
Molecular Weight329.4
XLogP3.8
Topological Polar Surface Area70.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity453
SMILES
C1=CC=C(C=C1)NC2=C(C=C3C(=C2)C(=O)NC3=O)NC4=CC=CC=C4
InChI
InChI=1S/C20H15N3O2/c24-19-15-11-17(21-13-7-3-1-4-8-13)18(12-16(15)20(25)23-19)22-14-9-5-2-6-10-14/h1-12,21-22H,(H,23,24,25)
InChIKey
AAALVYBICLMAMA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4,5-Dianilinophthalimide
CAS: 145915-58-8
CID: 1697
Formula: C20H15N3O2
MW: 329.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight329.4
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass329.116426730
Monoisotopic Mass329.116426730
Topological Polar Surface Area70.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity453
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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