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MS21

CAT: 0804-HY-141807-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-141807-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS21 is an effective AKT PROTAC degrader. MS21 can inhibit mutations in the PI3K/PTEN pathway, suppress the proliferation and induce cell cycle arrest of tumor cells. MS21 has anti-tumor activity. (Pink: AKT ligand-2 ; Black: Linker (HY-W014125) ; Blue: (S, R, S) -AHPC (HY-125845) ).
CAS Number
2376137-05-0
UNSPSC
12352005
Target
Akt; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms21.html
Purity
99.64
Solubility
Methanol : 95 mg/mL (ultrasonic)
Smiles
NC1(CCN(C2=NC=NC3=C2C=CN3)CC1)C(N[C@@H](CCN4CCN(C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)CC4)C8=CC=C(Cl)C=C8)=O
Molecular Formula
C58H79ClN12O6S
Molecular Weight
1107.84
References & Citations
[1]Xu J, et al. AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B. Cancer Discov. 2021 Jul 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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