VEGF-D

CAT: 0209-103-M66Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0209-103-M66Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.

Synonyms

Vascular endothelial growth factor D; Figf; Vegfd; VEGF-D; AI325264

NCBI Gene ID

14205

UniProt

O35251

Accession Number

NP_113949.1

Accession Number mRNA

NM_031761.1

Chromosomal Location

X F5; X 70.0 cM

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant mouse VEGF-D

Clone

(#8C35)

Applications

IHC, WB

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG

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Alternative Products

Catalog	Name
405509-01	VEGF-D
cyt-045-01	VEGF D
YP-W21898-01	Mouse VEGF-D (VEGF-D) ELISA Kit
220434	VEGF-D, Recombinant, Human (VEGF D, VEGF D, Vascular Endothelial Growth Factor-D) discontinued
OM301379-01	VEGF D Human
30R-AV020	VEGF D protein
396020	VEGF-D discontinued
5643-100	VEGF-D Antibody
Z03125-10	VEGF-D, Human
vAP-0003	Human VEGF-D

VEGF-D

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