VEGF-D

• Description:

  VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymph angiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1 kDa non-disulfide linked homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

• Synonyms:

  Vascular endothelial growth factor D; FIGF; VEGFD; VEGF-D

• NCBI Gene ID:

  2277

• UniProt:

  O43915

• Accession Number:

  NP_004460.1

• Accession Number mRNA:

  NM_004469

• Chromosomal Location:

  Xp22.31

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to bind recombinant human VEGFR3/Flt-4 Fc in a functional ELISA.

• Length:

  117

• Form:

  Lyophilized

• Molecular Weight:

  26.2 kDa

• Host or Source:

  HEK 293 cells