VEGF-C

• Description :

  VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

• Synonyms :

  Vascular endothelial growth factor C; Vegfc

• NCBI Gene ID :

  114111

• UniProt :

  O35757

• Accession Number :

  NP_446105.1

• Accession Number mRNA :

  NM_053653.1

• Chromosomal Location :

  16p11

• Reactivity :

  Anti-Rat

• Cross Reactivity :

  Rat

• Target Antigen :

  Recombinant rat VEGF-C (RT #R20-015)

• Clone :

  Rabbit IgG

• Applications :

  WB, E

• Purification Method :

  Protein A purified

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Bioactivity :

  Western Blot: Use 2-5 µg/ml

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  Water

• Storage Conditions :

  The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

• Host or Source :

  Rabbit