VEGF-C

CAT: 0209-101-M64Size: 50 µgDry Ice: NoHazardous: No

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CAT#:0209-101-M64Size:50 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed human VEGF-C is a 13.5 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

Synonyms

Vascular endothelial growth factor C; VEGFC; VRP; Flt4-L

NCBI Gene ID

7424

UniProt

P49767

Accession Number

NP_005420.1

Accession Number mRNA

NM_005429.2

Chromosomal Location

11q13

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human VEGF-C

Clone

(#2E65)

Applications

WB, IHC (P)

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Bioactivity

WB: 1:1000; IHC (Formalin/Paraffin) : 1:25-50

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

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