VEGF-B167

CAT: 0209-300-080SSize: 5 µgDry Ice: NoHazardous: No

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CAT#:0209-300-080SSize:5 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

Synonyms

Vascular endothelial growth factor B; VEGFB; VRF; VEGFL

NCBI Gene ID

7423

UniProt

P49765

Accession Number

NP_003368.1

Accession Number mRNA

NM_003377.4

Chromosomal Location

11Q13

Reactivity

Human

Cross Reactivity

Human

Sequence

MPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDSPRPLCPRCTQHHQRPDPRTCRCRCRRRSFLRCQGRGLELNPDTCRCRKLRR

Assay Protocol

The lyophilized VEGF-B167 should be reconstituted in water to a concentration not lower than 50 µg/ml. For long term storage we recommend to add at least 0.1% human or bovine serum albumin.

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & Coomassie stain

Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized human sVEGFR-1/Flt-1 at 1 µg/mL (100 µL/well) can bind rhVEGF-B167 with a linear range of 0.5 ng/mL to 12.5 ng/mL.

Length

167

Form

Lyophilized

Buffer

50mM acetic acid

Reconstitution

Water

Molecular Weight

38 kDa

Storage Conditions

Lyophilized samples are stable for greater than six months at –20°C to –70°C. Reconstituted VEGF-B167 should be stored in working aliquots at -20°C.

Host or Source

E. coli

N Terminal Sequence

MPVSQ

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MBS692275-01	Human VEGF-B167
102-PA72	Rabbit Anti-Human VEGF-B167
AP26032PU-L	VEGFB (VEGF-B167) Rabbit Polyclonal Antibody
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