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TNFSF7

CAT: 0209-103-M563Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-103-M563Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD27 ligand (CD27L), also named CD70, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7. Mouse CD27L cDNA encodes a 195 amino acid (aa) residue protein with a 23 aa N-terminal cytoplasmic domain, a 21 transmembrane domain and a 151 aa C‑terminal extracellular domain. Mouse and human CD27L share approximated 56% aa sequence identity. By analogy to other TNFSF ligands, CD27L is expected to exist as non-covalent homotrimers. The expression of CD27L is highly regulated at the transcription and posttranslational level. CD27L cell surface expression is induced by antigen receptor activation in B cells and at low levels in mouse T cells. Although CD27L expression is not detected on human dendritic cells (DC), membrane expression on mature mouse DCs has been reported. CD27L expression is also present in the thymus medulla in both human and mouse. CD27L interacts with CD27, a member of the TNF receptor superfamily that is expressed on natural killer (NK) cells and subsets of T and B cells.
Synonyms
CD27 Ligand, CD27-L; CD70 molecule, CD70, Ki-24 antigen, surface antigen CD70, TNFSF7, tumor necrosis factor (ligand) superfamily member 7
NCBI Gene ID
21948
UniProt
O55237
Accession Number
NP_035747.1
Accession Number mRNA
NM_011617.2
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant protein TNFSF7
Clone
(#9G24)
Applications
E, N/B
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG1

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