TNFSF4

CAT: 0209-101-M681Size: 100 µgDry Ice: NoHazardous: No
CAT#:0209-101-M681Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OX40 Ligand (OX40L), also known as gp34, is a member of the TNF superfamily. Human OX40L shares 46% amino acid sequence identity with its mouse counterpart. OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. Similar to other TNF superfamily members, membrane-bound OX40 Ligand exists as a homotrimer. OX40L binds to OX40 (CD134), a member of the TNF receptor superfamily, which is expressed predominantly on activated CD4+ T cells.
Synonyms
TNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; Ox 40 Ligand
NCBI Gene ID
7292
UniProt
P23510
Accession Number
NP_003317.1
Accession Number mRNA
NM_003326.3
Chromosomal Location
1q25
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human TNFSF4
Clone
(#8S23)
Applications
IHC (F), FC, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
FC: 1:50-100; IHC (frozen) : 1:20-200; Neutralization: In the presence of 10 ng/ml recombinant human OX40, ED50 of mouse anti-human Ox40L (101-M681; #8S23) is 0.5-1.5 µg/ml. --> The dose of the neutralization assay is for reference only and the final dose should be optimized by each user.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Notes
This antibody was selected for its ability to detect human TNFSF4.
Host or Source
Mouse
Isotype
IgG1

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