TNFRSF17 (BCMA)

• Description:

  B cell maturation protein (BCMA) is a member of the TNF receptor superfamily (TNFRSF17) . BCMA is expressed in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. BCMA binding to APRIL or BAFF stimulates IgM production in peripheral blood B cells and increases the survival of cultured B cells. Mature human and mouse BCMA share 86% amino acid sequence identity.

• Synonyms:

  TNFRSF17; BCM; BCMA; CD269

• NCBI Gene ID:

  608

• UniProt:

  Q02223

• Accession Number:

  NP_001183.2

• Accession Number mRNA:

  NM_001192.2

• Chromosomal Location:

  16p13.1

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human TNFRSF17 EC domain

• Clone:

  (#3D44)

• Applications:

  WB, Blocking

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2