BCMA

• Description:

  BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain. Recombinant soluble BCMA is a 50 amino acid polypeptide (5.3 kDa) comprising the TNFR homologous region of the BCMA protein.

• Synonyms:

  TNFRSF17; BCM; BCMA; CD269

• NCBI Gene ID:

  608

• UniProt:

  Q02223

• Accession Number:

  NP_001183

• Accession Number mRNA:

  NM_001192

• Chromosomal Location:

  16p13.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to neutralize APRIL-induced NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor.

• Length:

  50

• Form:

  Lyophilized

• Molecular Weight:

  5.3 kDa

• Host or Source:

  E. coli