TNF-alpha

CAT: 0209-R20-013Size: 20 µgDry Ice: NoHazardous: No
CAT#:0209-R20-013Size:20 µg
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Description
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant rat TNF-α is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
Synonyms
Tnf; Tnfa; RATTNF; TNF-alpha
NCBI Gene ID
24835
UniProt
P16599
Accession Number
NP_036807
Accession Number mRNA
NM_012675
Chromosomal Location
20p12
Reactivity
Rat
Cross Reactivity
Mouse, Rat, Bacteria, Human, Monkey
Sequence
MLRSSSQNSS DKPVAHVVAN HQAEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLIY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VSLLSAIKSP CPKDTPEGAE LKPWYEPMYL GGVFQLEKGD LLSAEVNLPK YLDITESGQV YFGVIAL
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Length
157
Form
Lyophilized
Molecular Weight
17.3 kDa
Host or Source
E. coli

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