TL-1A Recombinant Protein

TL-1A Recombinant Protein

• Description: TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues.
• Synonyms: TNFSF15; TL1; TL1A; VEGI; VEGI192A
• CAS Number: 9000-83-3
• NCBI Gene ID: 9966
• UniProt: O95150
• Accession Number: NP_005109
• Accession Number mRNA: NM_005118
• Gene Location: 9q32
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL
• Detection Range: Determined by its ability to stimulate IFN-γ production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Note: Results may vary with PBMC donors.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 194
• Form: Lyophilized
• Molecular Weight: 22 kDa
• Shipping Conditions: Room Temperature