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TFPI-2

CAT: 0209-101-M749Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M749Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Human TFPI is a physiological inhibitor of the extrinsic pathway of coagulation and functions in anticoagulation and anti-inflammation. It is a secreted protein with an N-terminal acidic region, three Kunitz (K) domains separated by two linker regions, and a C-terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF) . The second K domain inhibits factor Xa. The third K domain binds to heparin. The C-terminal basic region may have several functions. Human TFPI-2 is structurally similar to TFPI and is downregulated in several cancers.
Synonyms
TFPI2; PP5; REF1; TFPI-2
NCBI Gene ID
7980
UniProt
P483078
Accession Number
NP_006519.1
Accession Number mRNA
NM_006528.3
Chromosomal Location
7q22
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human TFPI-2
Clone
(#9F6)
Applications
WB, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:1000-2000; IHC (F) : 1:20-100
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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