TFF-3

• Description:

  The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to express in certain cancers, including colorectal, hepatocellular, and in biliary tumors. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation. Recombinant human TFF3 is a 13.2 kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

• Synonyms:

  TFF3; ITF; P1B; TFI

• NCBI Gene ID:

  7033

• UniProt:

  Q07654

• Accession Number:

  NP_0031217.3

• Accession Number mRNA:

  NM_003226

• Chromosomal Location:

  21q22.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 μg/ml.

• Length:

  59

• Form:

  Lyophilized

• Molecular Weight:

  13.2 kDa

• Host or Source:

  E. coli