TECK (CCL25)

• Description:

  TECK is a CC chemokine, specifically expressed by thymic stromal cells, and signals through the CCR9 receptor. TECK is chemotactic towards activated macrophages, thymocytes and dendritic cells. Recombinant human TECK is a 14.2 kDa protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

• Synonyms:

  CCL25; TECK; Ckb15; SCYA25

• NCBI Gene ID:

  6370

• UniProt:

  O15444

• Accession Number:

  NP_005615.2

• Accession Number mRNA:

  NM_005624

• Chromosomal Location:

  19p13.2

• Reactivity:

  Human

• Cross Reactivity:

  Hamster, Mouse, Human, Monkey, Bacteria

• Sequence:

  QGVFEDCCLA YHYPIGWAVL RRAWTYRIQE VSGSCNLPAA IFYLPKRHRK VCGNPKSREV QRAMKLLDAR NKVFAKLHHN MQTFQAGPHA VKKLSSGNSK LSSSKFSNPI SSSRKNVSLL ISANSGL

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to bind CCR9 receptor expressed on the surface of MOLT4 cells.

• Length:

  127

• Form:

  Lyophilized

• Molecular Weight:

  14.2 kDa

• Host or Source:

  E. coli