TACI (TNFRSF13B) Recombinant Protein
CAT:
209-100-285S
Size:
5 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TACI (TNFRSF13B) Recombinant Protein
- Description: TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.
- Synonyms: TNFRSF13B; CVID; TACI; CD267; CVID2; TNFRSF14B
- CAS Number: 9000-83-3
- NCBI Gene ID: 23495
- UniProt: O14836
- Accession Number: NP_036584.1
- Accession Number mRNA: NM_012452.2
- Gene Location: 17p11.2
- Host: E. coli
- Origin Species: Human
- Species Reactivity: Human
- Sequence: MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV
- Detection Range: Determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0-3.0 µg/ml.
- Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
- Purity: > 98% by SDS-PAGE & HPLC analyses
- Length: 160
- Form: Lyophilized
- Molecular Weight: 17.8 kDa
- Shipping Conditions: Room Temperature