Relaxin-3 Recombinant Protein

Relaxin-3 Recombinant Protein

• Description: Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an “orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain.
• Synonyms: RLN3; H3; RXN3; ZINS4; insl7
• CAS Number: 9000-83-3
• NCBI Gene ID: 117579
• UniProt: Q8WXF3
• Accession Number: NP_543140.1
• Accession Number mRNA: NM_080864
• Gene Location: 19p13.2
• Host: E. coli
• Origin Species: Human
• Species Reactivity: Human
• Sequence: A-chain: DVLAGLSSS CCKWGCSKSE ISSLC; B-chain: RAAPYGVRL CGREFIRAVI FTCGGSRW
• Detection Range: Data not available.
• Endotoxin: < 0.1 ng/µg of protein (<1EU/µg)
• Purity: > 98% by SDS-PAGE & HPLC analyses
• Length: 51
• Form: Lyophilized
• Molecular Weight: 5.5 kDa
• Shipping Conditions: Room Temperature