Goat Anti-Human RANKL Polyclonal Antibody

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAT:

209-102-P205G

Size:

100 µg

Price:

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Goat Anti-Human RANKL Polyclonal Antibody

Description: RANK Ligand (receptor activator of NFκB ligand [RANKL], also called TNFrelated activation induced cytokines (TRANCE), osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]), is a member of the tumor necrosis factor (TNF) family. RANK Ligand was originally identified as an immediate early gene upregulated by T cell receptor stimulation. The human RANK Ligand cDNA encodes a type II transmembrane protein of 317 amino acids with a predicted cytoplasmic domain of 47 amino acids, a 21 amino acids transmembrane region, and an extracellular domain of 249 amino acids. The extracellular domain contains two potential Nlinked glycosylation sites. Mouse and human RANK Ligand share 85% amino acid identity. RANK Ligand is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes. The multifunctions of RANK Ligand include induction of activation of the cjun N terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. RANK is the cell surface signaling receptor of RANK Ligand. RANK has been shown to undergo receptor clustering during signal transduction. Osteoprotegerin, a soluble member of the TNF receptor family which binds RANK Ligand, is a naturally occurring decoy receptor that counterbalances the effects of RANK Ligand.
Synonyms: TNFSF11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
NCBI Gene ID: 8600
UniProt: O14788
Accession Number: NP_003692.1
Accession Number mRNA: NM_003701.3
Gene Location: 13q14
Host: Goat
Origin Species: Human
Species Reactivity: Human
Target Antigen: Recombinant Human RANKL
Clone: Goat IgG
Validated Applications: ELISA, WB
Purification Method: Antigen-affinity purified
Form: Lyophilized from PBS
Buffer: PBS
Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Shipping Conditions: Room Temperature
Storage Conditions: The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

Complementary Product Range

Our range of products, including Goat Anti-Human RANKL Polyclonal Antibody, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

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