PD-1

CAT: 0209-101-M602Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M602Size:50 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Programmed Death1 (PD1) is a type I transmembrane protein belonging to the CD28/CTLA4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA4 and PD1) . PD1 is expressed on activated T cells, B cells, myeloid cells, and on a subset of thymocytes. In vitro, ligation of PD1 inhibits TCRmediated T cell proliferation and production of IL1, IL4, IL10, and IFNγ. In addition, PD1 ligation also inhibits BCR mediated signaling. PD1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Two B7 family proteins, PDL1 (also called B7H1) and PDL2 (also known as B7DC), have been identified as PD1 ligands. Unlike other B7 family proteins, both PDL1 and PDL2 are expressed in a wide variety of normal tissues including heart, placenta, and activated spleens. The wide expression of PDL1 and PDL2 and the inhibitor effects on PD1 ligation indicate that PD1 might be involved in the regulation of peripheral tolerance and may help prevent autoimmune diseases. The human PD1 gene encodes a 288 amino acid (aa) protein with a putative 20 aa signal peptide, a 148 aa extracellular region with one immuno-globulin-like V-type domain, a 24 aa transmembrane domain, and a 95 aa cytoplasmic region. The cytoplasmic tail contains two tyrosine residues that form the immunoreceptor tyrosinebased inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) that are important in mediating PD1 signaling. Mouse and human PD1 share approximately 60% aa sequence identity.
Synonyms
PDCD1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l
NCBI Gene ID
5133
UniProt
Q15116
Accession Number
NP_005009.2
Accession Number mRNA
NM_005018.2
Chromosomal Location
2q37.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human PD-1
Clone
(#9X21)
Applications
WB, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

Related Products

CatalogName
101-M604PD-L2
101-M603PD-ECGF
102-P23B7-H1/PD-L1 Fc
101-M758Gi24 (B7-H5, VISTA, PD-1H)
101-M759Gi24 (B7-H5, VISTA, PD-1H)
M60-046-L1000PD-L1 / B7-H1 / CD274 Protein (ECD, His Tag)
M60-046-L100PD-L1 / B7-H1 / CD274 Protein (ECD, His Tag)
600-051-L1000PD-L1 / B7-H1 / CD274 Protein (ECD, mFc Tag)
M60-045-L1000PD-L1 / B7-H1 / CD274 Protein (ECD, hFc Tag)
M60-045-L100PD-L1 / B7-H1 / CD274 Protein (ECD, hFc Tag)

Alternative Products

CatalogName
HY-160585PD-L1/PD-1-IN-1
abx283130-01PD-1/PD-L1 Inhibitor 1
HY-158052PD-1/PD-L1 antagonist 1
MBS191527-01PD-1
M28804-01PD-1/PD-L1-IN-10
HY-132192-01PD-1/PD-L1-IN-9
HY-152240-01PD-1/PD-L1-IN-29
HY-155740PD-1/PD-L1-IN-32
HY-144443PD-1/PD-L1-IN-16
MF-0039017-01PD-1/PD-L1-IN-NP19

Popular Products