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Pappalysin-2

CAT: 0209-101-M600Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M600Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pappalysins belong to a fifth family of metzincin proteases that consists of ADAMs/ADAMTSs, MMPs, astacins and serrylysins. PAPPA is an important pregnancy protein and increases in plasma by a factor of about 150 during pregnancy as compared to the non-pregnant state. PAPPA is also a major marker of Down syndrome in the first trimester of pregnancy because maternal serum levels of PAPPA are significantly reduced when a fetus affected by Down syndrome is present. PAPPA cleaves Insulin-like Growth FactorBinding Protein4 and 5 (IGFBP4 and 5) at a single site, resulting in the release of bioactive IGF. Compared to PAPPA, PAPPA2 (also called PAPPE), the second member of the family is less characterized. PAPPA2 shares 45% amino acid identity to PAPPA in the mature form, which is synthesized as a preproprotein consisting of multiple domains. The prepro region (residues 1-233) and the C-terminal region (residues 1397-1791) are not included in recombinant human PAPPA2.
Synonyms
PAPPA2; PAPPE; PLAC3; PAPP-A2
NCBI Gene ID
60676
UniProt
Q9BXP8
Accession Number
NP_064714.2
Accession Number mRNA
NM_020318.2
Chromosomal Location
1q23-q25
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human Pappalysin-2
Clone
(#8M12)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2

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