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Nidogen-1 (Entactin)

CAT: 0209-101-M816Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M816Size:50 µg
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Description
Nidogen-1 (also entactin) is a 150 kDa, secreted, monomeric glycoprotein that serves as a major linking component of basement membranes. It is synthesized as a 1247 amino acid (aa) precursor with a 28 aa signal sequence and a 1219 aa mature protein. The molecule is modular in structure with five distinct regions. Functionally, G1 is reported to bind type IV collagen. The mucin region contains a short peptide that ligates alpha 3 beta 1 integrins. G2 interacts with perlecan, and an RGD motif in the rod-shaped segment serves as a binding site for alpha v beta 3 integrins. Finally, G3 is associated with laminin binding.
Synonyms
Nidogen-1, NID-1, Entactin
NCBI Gene ID
4811
UniProt
P14543
Accession Number
NP_002499.2
Accession Number mRNA
NM_002508.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human Nidogen-1/Entactin
Clone
(#2R33)
Applications
EWB, E, IHC
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

UniProtKB · P14543

Nidogen-1

NID1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14543
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NID1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NID-1
EC number
—
Processing
Precursor
Secondary accessions
Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Basement membraneExtracellular matrixSecreted

Ligand

Calcium

Biological process

Cell adhesion

PTM

Disulfide bondGlycoproteinSulfation

Domain

EGF-like domainRepeatSignal

Technical term

Proteomics identificationReference proteome

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Alternative Products

CatalogName
MBS692672-01Nidogen-1 (Entactin)
MBS4381567-01Nidogen/Entactin
E3226-01Entactin (Nidogen)
169025Entactin (NiDogen) discontinued
E11General Entactin (Nidogen)
364355NID (Nidogen, Entactin)
MBS602420-01Nidogen (Entactin) G2
abx146317-01Nidogen 1/Entactin (NID1) Antibody
FY12331NID1 Antibody / Nidogen 1 / Entactin
298212Nidogen 1, Recombinant, Mouse (Entactin)

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