NGF-beta

• Description:

  Β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 14 kDa polypeptide monomers (240 total amino acid residues) . The three disulfide bonds are required for biological activity.

• Synonyms:

  NGF; NGFB; HSAN5; Beta-NGF

• NCBI Gene ID:

  4803

• UniProt:

  P01138

• Accession Number:

  NP_002497.2

• Accession Number mRNA:

  NM_002506

• Chromosomal Location:

  1p13.1

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant Human NGF-beta

• Applications:

  ELISA, N, WB, IHC

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Form:

  Lyophilized from PBS

• Buffer:

  PBS

• Reconstitution:

  Water

• Storage Conditions:

  The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.

• Host or Source:

  Mouse

• Isotype:

  IgG1